SUMMARY OF SNP (June, 2013)

Classification of SNP: Medium sized scope (over 100 submissions predicted). PF825 is a son of Z253. This Y-SNP is dominated by the McClure and McCracken surnames (50 %) but includes many diverse surnames as well. PF825 already satifies the ISOGG requirements and its addition to the ISOGG haplotree is pending review. There are at least two independent mutations of this YSNP as FTDNA ID N98559 (Scottish project) tested PF825 positive and is A-M202 positive as well.

Estimated Breadth of SNP (over 70 % match): Over 130 testing candidates found.

Scope of Testing within Fingerprint: Below average - only three have tested positive under R-L21 to date.

Dominant Surname (predicted positive): McClure and McCracken (around 50 %). Many other surnames found as well.

Year that SNPs were discovered: February, 2013 (Nat Geo test).

Source of SNP: Nat Geo test - McClure, FTDNA 99512, Y-Search - CEGBJ.

Number of Positive Tests: Three known (under R-L21).

Number of Negative Broad Tests: Around 17 negative tests (primarily Nat Geo tests).

Number of Negative Tests within Fingerprint (over 70 % match): None.

Possible Untested Candidates (over 70 % match): Around 130.

Pending Tests (within Fingerprint): None known.

TRENDS OF TESTING CANDIDATES

PF825 Fingerprint

The curve associated with the testing candidates appears to be typical for L21 SNPs where the number of testing candidates declines down to 70 % matches, remains low between 50 and 70 % and then sees a sharp rise as non-PF825 submissions dominate the under 50 % matches.

ISOGG Status - Prove relationship of PF825 to other L21 SNPs

Requirements for proving PF825's position on the ISOGG haplotree have been met and the new genetic distance requirement of 10 % has been met. PF825 has not been added to the ISOGG haplotree but is pending approval. Below is a summary of SNPs tested:

DNA FINGERPRINTS

L21 Off Modal Mutations:

Markers 1 to 37: 392 >= 15, 448 <= 18, 449 <= 29, 464b >= 16, 464c <= 16, 456 <= 15, 607 <= 14 and 576 >= 19 (8 mutations).

Markers 38 to 67: 557 >= 17 and 444 >= 13 (2 mutations).

DNA Signature (L21 Plus project): 253-1716-Mc.

Markers 1 to 37: 392 >= 15, 448 <= 18, 464b = 16, 464c = 16 and 607 <= 14 (5 mutations).

Markers 38 to 67: 557 >= 17 and 444 >= 13 (2 mutations).

392 >= 15 appears to be the primary key marker within the PF825 fingerprint. This means that these mutations happened very close to the creation of the PF825 mutation. 607 <=14 is another possible key mutation but is less significant that marker 392. 391 <= 10 appears to be a significan post PF825 mutation (20 % of good testing candidates).

Testing Candidate Recommendations

For a detailed list of good testing candidates, see the spreadsheet of testing candidates which can be found in the PF825 link in the DNA Results pull down menu. Here are the priorities for testing:

1) Almost every submission that are 90 % or higher matches (9 of 10 matches and higher) will probably test positive. Since around half of the testing candidates are either McClure or McCracken submissions, it is only recommended that higher genetic distance testing candidates be tested for these surnames (the lowest three or four in the spreadsheet) for 90 % or higher matches.

2) For submissions that are not McClure or McCracken, only higher genetic distance matches (upper 25 %) should be tested for fingerprint matches of 9 of 10 or 10 of 10 matches. Exceptions include submissions have unique surnames for the testing candidates (only one or two with the surname are found on the list).

3) Virtually all 7 of 10 and 8 of 10 matches should be tested. Most 7 of 10 matches will test negative but many will also test positive (only 10 to 20 percent should test positive). Probably 70 % of the 8 of 10 matches will test positive. Even a few 6 of 10 matches could test positive (less than five percent). With over 177 testing candidates at 6 of 10 matches, these submissions were not included until the real scope of PF825 is revealed by extensively testing 7 of 10 and 8 of 10 matches.